M-Floxsel Tablets 400mg – Broad-Spectrum Fluoroquinolone Antibacterial Therapy

Product Overview

M-Floxsel Tablets 400mg is a high-potency, broad-spectrum fourth-generation fluoroquinolone antibacterial agent containing Moxifloxacin Hydrochloride (400mg). Engineered for oral administration, M-Floxsel delivers rapid systemic absorption and excellent tissue penetration. It is indicated for the treatment of moderate-to-severe bacterial infections of the upper and lower respiratory tract, acute bacterial sinusitis, community-acquired pneumonia (CAP), acute bacterial exacerbations of chronic bronchitis (ABECB), complicated skin and skin structure infections (cSSSI), and complicated intra-abdominal infections.

Key Benefits

• Advanced Fourth-Generation Fluoroquinolone: Features enhanced activity against Gram-positive pathogens, atypical organisms, and anaerobic bacteria compared to earlier quinolones.

• Potent Respiratory Coverage: Highly effective against primary respiratory pathogens, including penicillin-resistant Streptococcus pneumoniae (PRSP).

• Convenient Once-Daily Dosing: High oral bioavailability enables simple, once-daily administration for optimal patient compliance.

• Rapid Systemic Absorption: Reaches peak plasma concentrations rapidly, providing bioequivalent exposure comparable to intravenous therapy.

• Broad-Spectrum Bactericidal Action: Effectively eradicates susceptible strains of Gram-negative, Gram-positive, atypical, and anaerobic pathogens.

How It Works

M-Floxsel Tablets 400mg (Moxifloxacin) exert rapid bactericidal action by inhibiting dual essential bacterial enzymes required for DNA synthesis: bacterial topoisomerase IV and DNA gyrase (topoisomerase II). DNA gyrase is responsible for uncoiling supercoiled DNA during replication and transcription, while topoisomerase IV is crucial for separating daughter chromosome strands during cell division. By targeting both enzymes simultaneously, M-Floxsel impairs bacterial chromosome replication, preventing repair and triggering rapid cell death.

Key Active Ingredients

• Moxifloxacin Hydrochloride (400mg per film-coated tablet): Synthetic 8-methoxyfluoroquinolone antibacterial agent that inhibits bacterial DNA replication to eradicate complex infections.

Directions for Use

1. Administration: Swallow the tablet whole with a full glass of water. Do not crush, chew, or split the tablet.

2. Timing: Take once daily (400mg), with or without food, at the same time each day to maintain stable plasma levels.

3. Hydration: Ensure adequate daily fluid intake while taking fluoroquinolone therapy.

4. Treatment Duration: Complete the full course of therapy (typically 5 to 14 days based on clinical indication) as prescribed by your physician.

Precautions

• Prescription-Only Medication: Use strictly under the direction and supervision of a licensed healthcare professional.

• Black Box / Serious Warning: Fluoroquinolones are associated with risks of tendonitis, tendon rupture (especially Achilles tendon), peripheral neuropathy, central nervous system effects, and aortic aneurysm/dissection. Discontinue immediately if tendon pain, swelling, or numbness occurs.

• QT Prolongation: Exercise caution in patients with known prolongation of the QT interval, uncorrected hypokalemia, or those taking antiarrhythmic agents (Class IA or Class III).

• Cation Interactions: Antacids containing magnesium or aluminum, sucralfate, iron supplements, or multivitamins containing zinc impair absorption; take M-Floxsel at least 4 hours before or 8 hours after these agents.

• Consult a doctor before use during pregnancy or lactation.

• Keep out of reach of children.

Storage Instructions

Store in a cool, dry place below 30°C, protected from direct light, excessive heat, and moisture. Retain tablets in their original blister packaging until use.

Manufacturer Information

Formulated and manufactured in strict compliance with international pharmaceutical quality standards, dedicated to producing high-potency anti-infective formulations designed to combat resistant microbial pathogens and improve patient health outcomes.