Hicartif Injection – Intra-Articular Viscosupplementation & Joint Protection

Hicartif Injection is a specialized intra-articular viscoelastic supplement containing high-molecular-weight Sodium Hyaluronate / Cartilage Protection Complex. Engineered for direct intra-articular administration into affected joint spaces, Hicartif restores the natural rheological properties of synovial fluid degraded by osteoarthritis or traumatic joint damage. By cushioning articular cartilage, enhancing fluid viscosity, and suppressing intra-articular inflammatory signaling, Hicartif provides long-lasting relief from joint pain, stiffness, and mechanical friction, allowing patients with knee, hip, or shoulder osteoarthritis to regain smooth, pain-free mobility.

Key Benefits

• Effective Viscosupplementation: Restores viscoelasticity and shock-absorbing properties to depleted synovial fluid.

• Targeted Joint Pain Relief: Reduces intra-articular friction and mechanical wear to relieve chronic osteoarthritic pain and stiffness.

• Chondroprotective Properties: Protects remaining articular cartilage matrix from mechanical degradation and enzymatic breakdown.

• Improves Joint Mobility: Enhances range of motion and joint flexibility, supporting daily functional activity and rehabilitation.

• Targeted Intra-Articular Delivery: Bypasses systemic side effects by acting locally within the synovial joint capsule.

How It Works

Hicartif Injection acts as a viscoelastic lubricant and structural biopolymer within the synovial cavity. In healthy joints, high concentrations of endogenous hyaluronic acid maintain synovial fluid viscosity and elasticity. In osteoarthritis, molecular weight and concentration drop significantly, causing friction and cartilage destruction. Hicartif replenishes this fluid matrix, restoring shock absorption during load-bearing impact. Additionally, it interacts with cellular CD44 receptors on chondrocytes and synoviocytes, inhibiting pro-inflammatory cytokines (such as IL-1$\beta$) and slowing cartilage matrix degradation.

Key Active Ingredients

• Sodium Hyaluronate / Viscoelastic Complex: Purified, highly biocompatible intra-articular viscosupplement that restores synovial fluid elasticity, cushions bone ends, and protects cartilage.

Directions for Use

1. Administration: Strictly for Intra-Articular Injection into the synovial cavity of the affected joint (e.g., knee, shoulder, hip). Never administer intravenously or extravascularly.

2. Clinical Protocol: Administered as a single-dose regimen or a weekly series of 3 to 5 injections, as evaluated and prescribed by an orthopedic specialist.

3. Preparation: Remove any joint effusion via arthrocentesis prior to injecting Hicartif into the joint space.

4. Professional Healthcare Use: Must be administered exclusively by a qualified orthopedic surgeon, rheumatologist, or trained medical specialist using aseptic technique.

Precautions

• Prescription-Only Intra-Articular: For specialist healthcare facility administration only; strictly prohibited for self-administration.

• Contraindications: Do not inject into joints with active infections, skin diseases, or open wounds in the immediate injection site area.

• Avoid strenuous activity or high-impact, load-bearing exercises for 48 hours following the injection.

• Temporary post-injection reactions such as mild joint pain, swelling, or localized heat may occur; applying a cold pack for 5 to 10 minutes can alleviate discomfort.

• Consult a physician before use during pregnancy or lactation.

• Keep out of reach of children.

Storage Instructions

Store in a cool, dry place between 2°C and 25°C, protected from direct sunlight, heat, and moisture. Do not freeze. Retain in original packaging until ready for sterile administration.

Manufacturer Information

Formulated and manufactured in strict compliance with international pharmaceutical quality standards, dedicated to developing targeted orthopedic and rheumatology therapies that restore joint mobility and enhance patient quality of life.