Feroject Injection – Intravenous Iron Sucrose Therapy for Anemia

Product Overview

Feroject Injection is a specialized parenteral iron replacement therapy containing Iron Sucrose (50mg/ml). Formulated for intravenous administration, Feroject rapidly restores iron stores, elevates hemoglobin concentrations, and supports red blood cell production in patients with iron deficiency anemia. It is specifically indicated when oral iron supplements are ineffective, poorly tolerated, non-compliant, or clinically contraindicated—such as in patients with severe gastrointestinal intolerance, chronic kidney disease (CKD), inflammatory bowel disease, or post-operative blood loss.

Key Benefits

• Rapid Iron Store Repletion: Direct intravenous delivery quickly replenishes depleted ferritin levels and speeds up hemoglobin synthesis.

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• Bypasses Gastrointestinal System: Eliminates severe stomach upset, constipation, and poor mucosal absorption associated with oral iron therapy.

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• Crucial Support for Chronic Kidney Disease (CKD): Ideal for managing anemia in patients undergoing hemodialysis or receiving erythropoietin-stimulating agents.

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• High Targeted Efficacy: Accelerates functional red blood cell production to relieve chronic fatigue, weakness, and dizziness.

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• Parenteral Safety Profile: Lower risk of severe anaphylactoid reactions compared to older high-molecular-weight iron dextran formulations.

How It Works

Feroject Injection (Iron Sucrose) consists of a polynuclear iron(III)-hydroxide core surrounded by a sucrose shell. Following intravenous infusion, the complex is selectively taken up by cells of the reticuloendothelial system (RES), primarily in the liver, spleen, and bone marrow. Within the RES, the iron sucrose complex dissociates into elemental iron and sucrose. The released elemental iron is then bound to endogenous transferrin for immediate transport to bone marrow for erythropoiesis or stored safely in ferritin and hemosiderin complexes for future hemoglobin synthesis.

Key Active Ingredients

• Iron Sucrose (50mg elemental Iron per ml): Parenteral iron replacement complex that replenishes systemic iron reserves and drives active hemoglobin production.

Directions for Use

1. Administration: For Slow Intravenous (IV) Injection or IV Drip Infusion only. Never administer via intramuscular or subcutaneous routes.

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2. Dilution for Infusion: Dilute strictly in sterile 0.9% Sodium Chloride (Normal Saline) solution prior to intravenous drip infusion.

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3. Clinical Dosing: Dosage is calculated individually based on the patient’s total iron deficit using the Ganzoni equation:

   $$\text{Total Iron Deficit (mg)}=\text{Body Weight (kg)}\times (\text{Target Hb}-\text{Actual Hb (g/dl)})\times 2.4+\text{Depot Iron (mg)}$$

4. Professional Healthcare Use: Must be administered under the direct supervision of a healthcare professional in a clinic or hospital environment equipped to manage hypersensitivity reactions.

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Precautions

• Prescription-Only Parenteral: For clinical, inpatient, or hospital administration only; strictly avoid self-administration.

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• Hypersensitivity Alert: Monitor patients closely for signs of allergic reactions or anaphylaxis during and for at least 30 minutes following administration.

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• Contraindications: Contraindicated in patients with iron overload syndromes (hemochromatosis, hemosiderosis), non-iron deficiency anemias (e.g., hemolytic anemia, vitamin B12 deficiency), or known hypersensitivity to iron sucrose complex.

• Administration Speed: Avoid rapid IV push; fast injection rates can trigger transient hypotension or flushing.

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• Pregnancy & Lactation: Use during the second and third trimesters only when clinically necessary under strict medical supervision.

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• Keep out of reach of children.

Storage Instructions

Store in a cool, dry place below 30°C. Protect from light and extreme heat. Do not freeze. Use the prepared IV infusion solution immediately following dilution.

Manufacturer Information

Formulated and manufactured in strict compliance with international pharmaceutical quality standards, dedicated to providing targeted hematology and parenteral care therapies that restore patient vitality and optimize clinical outcomes.