Artisol-M Tablet 50mg – Artemether & Lumefantrine Antimalarial Therapy

Product Overview

Artisol-M Tablet 50mg is a fixed-dose Artemisinin-based Combination Therapy (ACT) formulated for the rapid treatment of acute, uncomplicated Plasmodium falciparum malaria infections. Combining Artemether (50mg) and Lumefantrine, Artisol-M delivers a dual-action mechanism that quickly clears circulating blood-stage malaria parasites and eliminates residual schizonts to prevent recrudescence and treatment failure. Designed to combat drug-resistant malarial strains, Artisol-M provides safe, effective, and complete parasite eradication when taken as part of a full treatment course.

Key Benefits

• Effective Antimalarial Clearance: Rapidly reduces malaria parasite burden in the bloodstream to relieve fever and clinical symptoms.

• Dual-Action Synergistic Formula: Combines a fast-acting artemisinin derivative with a long-acting antimalarial to ensure complete parasite eradication.

• Combats Resistant Strains: Highly effective against Plasmodium falciparum strains resistant to traditional monotherapies like chloroquine.

• Prevents Disease Recrudescence: The extended half-life of lumefantrine suppresses lingering parasites, preventing disease relapse.

• Targeted Dosing: Formulated for precise weight-based administration in pediatric and adult clinical regimens.

How It Works

Artisol-M Tablet 50mg operates through a complementary two-stage parasiticidal action. Artemether is rapidly absorbed and bioactivated within the parasite’s food vacuole, reacting with intra-parasitic iron to generate toxic free radicals and reactive oxygen species (ROS) that destroy parasite membranes and proteins. This causes a swift drop in parasite density. Lumefantrine, a longer-acting arylamino alcohol, inhibits the detoxification of toxic micro-heme into inert hemozoin within the parasite, causing lethal toxic buildup that clears any remaining parasites over the subsequent days.

Key Active Ingredients

• Artemether (50mg): Fast-acting artemisinin derivative responsible for rapid parasite clearance and fever resolution.

• Lumefantrine: Long-acting antimalarial agent that eliminates residual parasites and prevents reinfection/recrudescence.

Directions for Use

1. Administration: Take orally with fat-containing food or drinks (such as milk, meal, or infant formula) to enhance lumefantrine absorption.

2. Standard 3-Day Regimen:

   • Initial Dose: Take the first dose at diagnosis.

   • Second Dose: Take 8 hours after the first dose.

   • Subsequent Doses: Take twice daily (morning and evening) for the next 2 days (total of 6 doses over 60 hours).

3. Exact Dosage: Dosage depends strictly on body weight and clinical prescription. Always complete the entire 6-dose course even if symptoms disappear early.

Precautions

• Prescription-only medication; use strictly under medical supervision.

• Do not use for malaria prophylaxis (prevention); indicated for acute treatment only.

• Exercise caution in patients with severe hepatic or renal impairment, cardiac arrhythmias, or prolonged QTc intervals.

• Re-administer the full dose if vomiting occurs within 1 hour of ingestion; consult a physician if vomiting persists.

• Discontinue immediately and seek emergency medical care if hypersensitivity reactions or severe skin rashes occur.

• Keep out of reach of children.

Storage Instructions

Store in a cool, dry place below 30°C, protected from direct sunlight, heat, and moisture. Keep tablets in their original blister packaging until use.

Manufacturer Information

Formulated and manufactured in strict compliance with international pharmaceutical quality standards, dedicated to providing high-potency antimalarial therapies that safeguard public health and eliminate parasitic infections.