CEZOTUM 1g & 2g Injection (Cefoperazone + Sulbactam) | Pharma Services Group

CEZOTUM Injection is a combination antibiotic containing Cefoperazone and Sulbactam, available in 1g and 2g strengths for intravenous (IV) or intramuscular (IM) administration. The supplied packaging clearly identifies CEZOTUM 2g as Cefoperazone + Sulbactam Injection and indicates that it is intended for IV/IM use. Regulatory and pharmaceutical product records also identify CEZOTUM 1g as a Cefoperazone + Sulbactam injection.

Cefoperazone + Sulbactam injection is a broad-spectrum antibacterial combination used for the treatment of susceptible bacterial infections. Cefoperazone inhibits bacterial cell-wall formation, while Sulbactam inhibits beta-lactamase enzymes that can otherwise reduce the effectiveness of certain beta-lactam antibiotics. Together, the combination provides antibacterial activity against a range of susceptible organisms and may be prescribed for serious infections involving the respiratory tract, urinary tract, abdomen, skin and soft tissues, bones and joints, and other sites when clinically appropriate.

Available Strengths

The supplied 2g pack specifically shows Cefoperazone 1g + Sulbactam 1g. The 1g CEZOTUM presentation is documented as a Cefoperazone + Sulbactam product, but the exact component ratio should be confirmed from the current pack/leaflet before publishing the numerical composition for that strength.

Key Benefits

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• Contains the antibiotic combination Cefoperazone + Sulbactam.
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• Available in 1g and 2g injection strengths.
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• Provides broad-spectrum antibacterial activity against susceptible bacteria.
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• Sulbactam helps inhibit beta-lactamase enzymes and can enhance Cefoperazone activity.
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• Used for the treatment of various bacterial infections.
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• Suitable for IV or IM administration by qualified healthcare professionals.
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• May be used in hospital and clinical settings for infections requiring injectable antibiotic therapy.
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How It Works

Cefoperazone is a third-generation cephalosporin antibiotic that works by interfering with bacterial cell-wall synthesis. This weakens the bacterial cell wall and ultimately leads to the death of susceptible bacteria.

Sulbactam is a beta-lactamase inhibitor. It blocks certain beta-lactamase enzymes produced by bacteria, helping protect Cefoperazone from enzymatic breakdown and enhancing its antibacterial activity.

Uses / Therapeutic Applications

CEZOTUM may be prescribed for susceptible bacterial infections, including certain infections involving:

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• Lower respiratory tract and lung
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• Urinary tract
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• Skin and soft tissues
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• Abdomen and intra-abdominal structures
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• Bones and joints
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• Bloodstream/systemic infections
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• Other serious bacterial infections determined by the treating physician
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The exact indication depends on the suspected or confirmed organism, infection site, severity and local antibiotic-susceptibility patterns.

Directions for Use

CEZOTUM Injection must be prepared and administered by a doctor, nurse or other qualified healthcare professional. It may be administered intravenously or intramuscularly according to the prescribed regimen and product instructions.

The appropriate strength, dose, frequency and treatment duration depend on the type and severity of infection, the patient's age, weight, kidney and liver function, and the susceptibility of the bacteria.

Do not self-inject CEZOTUM and do not use the 1g and 2g presentations interchangeably without medical direction.

Precautions

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• CEZOTUM is a prescription antibiotic and should be used only under medical supervision.
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• Tell your doctor if you have previously experienced an allergy to Cefoperazone, cephalosporins, penicillins or other beta-lactam antibiotics.
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• Inform your doctor about kidney or liver disease.
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• Tell your healthcare professional about all medicines you are taking.
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• Cefoperazone may affect blood coagulation in some patients; inform your doctor if you have a bleeding disorder or are taking anticoagulant medicines.
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• Avoid unnecessary alcohol consumption during treatment and follow your physician's advice.
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• Antibiotics should not be used for viral infections such as ordinary colds or influenza.
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• Complete the prescribed antibiotic course unless your doctor specifically advises you to stop.
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• Seek immediate medical help for severe rash, facial swelling, difficulty breathing or other signs of a serious allergic reaction.
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Possible Side Effects

Possible side effects of Cefoperazone + Sulbactam may include diarrhea, nausea, vomiting, abdominal discomfort, headache, injection-site reactions and changes in liver enzymes. Changes in blood counts or coagulation parameters may also occur in some patients.

Contact a healthcare professional if diarrhea becomes severe or persistent, particularly if it is accompanied by abdominal cramps or blood in the stool. Serious allergic reactions require immediate medical attention.

Storage Instructions

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• Store according to the manufacturer's recommended temperature.
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• Protect the unopened vial from excessive heat, moisture and direct sunlight.
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• Keep the injection in its original packaging.
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• Keep out of reach of children.
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• Reconstituted solutions should be prepared, stored and used according to the approved product information and healthcare-facility procedures.
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• Do not use the product after its expiry date.
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Manufacturer Information

Brand: CEZOTUM \nGeneric Name: Cefoperazone + Sulbactam \nAvailable Strengths: 1g & 2g \nDosage Form: Powder for Injection \nRoutes: IV / IM \nMarketer: Unimark Remedies Ltd.

Product records identify CEZOTUM 1g as Cefoperazone + Sulbactam for Injection and associate the product with Unimark Remedies Ltd.

Product Specifications