{"product_id":"esover-injection-40mg-intravenous-proton-pump-inhibitor-therapy","title":"Esover Injection 40mg - Intravenous Proton Pump Inhibitor Therapy","description":"\u003cdiv class=\"container\"\u003e\r\\n\u003cdiv id=\"model-response-message-contentr_33adfe8db0f1fb05\" class=\"markdown markdown-main-panel md-content animate enable-luminous-fast-follows enable-updated-hr-color tutor-markdown-rendering\" dir=\"ltr\" aria-busy=\"true\" aria-live=\"polite\"\u003e\r\\n\u003ch2 data-path-to-node=\"9\"\u003eProduct Overview\u003c\/h2\u003e\r\\n\u003cp data-path-to-node=\"10\"\u003e\u003cb data-path-to-node=\"10\" data-index-in-node=\"0\"\u003eEsover Injection 40mg\u003c\/b\u003e is a high-potency parenteral Proton Pump Inhibitor (PPI) formulation containing \u003cb data-path-to-node=\"10\" data-index-in-node=\"102\"\u003eEsomeprazole Sodium (40mg)\u003c\/b\u003e. Engineered for immediate systemic bioavailability via Intravenous (IV) injection or infusion, Esover Injection provides rapid and sustained suppression of gastric acid production. It is indicated for the acute management of severe Gastroesophageal Reflux Disease (GERD) with esophagitis, short-term treatment of gastric and duodenal ulcers when oral therapy is not feasible, and the prevention of rebleeding following therapeutic endoscopy for acute bleeding peptic ulcers.\u003c\/p\u003e\r\\n\r\\n\u003ch3 data-path-to-node=\"11\"\u003eKey Benefits\u003c\/h3\u003e\r\\n\u003cul data-path-to-node=\"12\"\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"12,0,0\"\u003e\u003cb data-path-to-node=\"12,0,0\" data-index-in-node=\"0\"\u003eRapid \u0026amp; Potent Acid Suppression:\u003c\/b\u003e Delivers immediate systemic action to halt gastric acid production in critical inpatient scenarios.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"12,1,0\"\u003e\u003cb data-path-to-node=\"12,1,0\" data-index-in-node=\"0\"\u003eEffective Bleeding Ulcer Management:\u003c\/b\u003e Maintains high intragastric pH levels (\u003cspan class=\"math-inline\" data-math=\"\u0026gt;6.0\" data-index-in-node=\"76\"\u003e\u003cspan class=\"katex\"\u003e\u003cspan class=\"katex-html\" aria-hidden=\"true\"\u003e\u003cspan class=\"base\"\u003e\u003cspan class=\"mrel\"\u003e\u0026gt;\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"base\"\u003e\u003cspan class=\"mord\"\u003e6.0\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e) to stabilize blood clots and prevent recurrent peptic ulcer rebleeding.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"12,2,0\"\u003e\u003cb data-path-to-node=\"12,2,0\" data-index-in-node=\"0\"\u003eParenteral Alternative to Oral PPIs:\u003c\/b\u003e Serves as a vital therapeutic option for surgical, unconscious, or dysphagic patients unable to take oral medications.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"12,3,0\"\u003e\u003cb data-path-to-node=\"12,3,0\" data-index-in-node=\"0\"\u003ePrevents Stress-Induced Mucosal Damage:\u003c\/b\u003e Protects critically ill patients in ICU settings from acute gastric mucosal lesions and stress ulcers.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"12,4,0\"\u003e\u003cb data-path-to-node=\"12,4,0\" data-index-in-node=\"0\"\u003eTargeted 24-Hour Protection:\u003c\/b\u003e Sustains elevated gastric pH to promote rapid mucosal healing and esophageal tissue recovery.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n\u003c\/ul\u003e\r\\n\u003ch3 data-path-to-node=\"13\"\u003eHow It Works\u003c\/h3\u003e\r\\n\u003cp data-path-to-node=\"14\"\u003e\u003cspan class=\"animating\"\u003eEsover Injection 40mg (Esomeprazole Sodium) acts as a targeted inhibitor of the gastric \u003c\/span\u003e\u003cb class=\"\" data-path-to-node=\"14\" data-index-in-node=\"88\"\u003e\u003cspan class=\"math-inline\" data-math=\"H^+\/K^+\" data-index-in-node=\"88\"\u003e\u003cspan class=\"katex\"\u003e\u003cspan class=\"katex-html\" aria-hidden=\"true\"\u003e\u003cspan class=\"base\"\u003e\u003cspan class=\"mord\"\u003e\u003cspan class=\"mord mathnormal\"\u003eH\u003c\/span\u003e\u003cspan class=\"msupsub\"\u003e\u003cspan class=\"vlist-t\"\u003e\u003cspan class=\"vlist-r\"\u003e\u003cspan class=\"vlist\"\u003e\u003cspan class=\"\"\u003e\u003cspan class=\"sizing reset-size6 size3 mtight\"\u003e\u003cspan class=\"mbin mtight\"\u003e+\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"mord\"\u003e\/\u003c\/span\u003e\u003cspan class=\"mord\"\u003e\u003cspan class=\"mord mathnormal\"\u003eK\u003c\/span\u003e\u003cspan class=\"msupsub\"\u003e\u003cspan class=\"vlist-t\"\u003e\u003cspan class=\"vlist-r\"\u003e\u003cspan class=\"vlist\"\u003e\u003cspan class=\"\"\u003e\u003cspan class=\"sizing reset-size6 size3 mtight\"\u003e\u003cspan class=\"mbin mtight\"\u003e+\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e-ATPase enzyme system\u003c\/b\u003e (the proton pump) located on the secretory surface of parietal cells in the stomach lining. Following intravenous administration, Esomeprazole accumulates in the acidic secretory canaliculi of parietal cells, where it is converted into its active sulfenamide derivative. This reactive form irreversibly binds to cysteine residues on the \u003cspan class=\"math-inline\" data-math=\"H^+\/K^+\" data-index-in-node=\"454\"\u003e\u003cspan class=\"katex\"\u003e\u003cspan class=\"katex-html\" aria-hidden=\"true\"\u003e\u003cspan class=\"base\"\u003e\u003cspan class=\"mord\"\u003e\u003cspan class=\"mord mathnormal\"\u003eH\u003c\/span\u003e\u003cspan class=\"msupsub\"\u003e\u003cspan class=\"vlist-t\"\u003e\u003cspan class=\"vlist-r\"\u003e\u003cspan class=\"vlist\"\u003e\u003cspan class=\"\"\u003e\u003cspan class=\"sizing reset-size6 size3 mtight\"\u003e\u003cspan class=\"mbin mtight\"\u003e+\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"mord\"\u003e\/\u003c\/span\u003e\u003cspan class=\"mord\"\u003e\u003cspan class=\"mord mathnormal\"\u003eK\u003c\/span\u003e\u003cspan class=\"msupsub\"\u003e\u003cspan class=\"vlist-t\"\u003e\u003cspan class=\"vlist-r\"\u003e\u003cspan class=\"vlist\"\u003e\u003cspan class=\"\"\u003e\u003cspan class=\"sizing reset-size6 size3 mtight\"\u003e\u003cspan class=\"mbin mtight\"\u003e+\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e-ATPase enzyme, blocking the final, common pathway of gastric acid generation and reducing both basal and stimulated acid output.\u003c\/p\u003e\r\\n\r\\n\u003ch3 data-path-to-node=\"15\"\u003eKey Active Ingredients\u003c\/h3\u003e\r\\n\u003cul data-path-to-node=\"16\"\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"16,0,0\"\u003e\u003cb data-path-to-node=\"16,0,0\" data-index-in-node=\"0\"\u003eEsomeprazole Sodium (40mg per vial):\u003c\/b\u003e Intravenous substituted benzimidazole proton pump inhibitor that blocks parietal cell \u003cspan class=\"math-inline\" data-math=\"H^+\/K^+\" data-index-in-node=\"123\"\u003e\u003cspan class=\"katex\"\u003e\u003cspan class=\"katex-html\" aria-hidden=\"true\"\u003e\u003cspan class=\"base\"\u003e\u003cspan class=\"mord\"\u003e\u003cspan class=\"mord mathnormal\"\u003eH\u003c\/span\u003e\u003cspan class=\"msupsub\"\u003e\u003cspan class=\"vlist-t\"\u003e\u003cspan class=\"vlist-r\"\u003e\u003cspan class=\"vlist\"\u003e\u003cspan class=\"\"\u003e\u003cspan class=\"sizing reset-size6 size3 mtight\"\u003e\u003cspan class=\"mbin mtight\"\u003e+\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"mord\"\u003e\/\u003c\/span\u003e\u003cspan class=\"mord\"\u003e\u003cspan class=\"mord mathnormal\"\u003eK\u003c\/span\u003e\u003cspan class=\"msupsub\"\u003e\u003cspan class=\"vlist-t\"\u003e\u003cspan class=\"vlist-r\"\u003e\u003cspan class=\"vlist\"\u003e\u003cspan class=\"\"\u003e\u003cspan class=\"sizing reset-size6 size3 mtight\"\u003e\u003cspan class=\"mbin mtight\"\u003e+\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e-ATPase to suppress gastric acid release.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n\u003c\/ul\u003e\r\\n\u003ch3 data-path-to-node=\"17\"\u003eDirections for Use\u003c\/h3\u003e\r\\n\u003col start=\"1\" data-path-to-node=\"18\"\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"18,0,0\"\u003e\u003cb data-path-to-node=\"18,0,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e Reconstitute the 40mg powder vial with 5ml of 0.9% Sodium Chloride Injection for IV injection, or dilute further in 50ml\/100ml of 0.9% Sodium Chloride for IV infusion.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"18,1,0\"\u003e\u003cb data-path-to-node=\"18,1,0\" data-index-in-node=\"0\"\u003eAdministration:\u003c\/b\u003e\u003c\/p\u003e\r\\n\r\\n\u003cul data-path-to-node=\"18,1,1\"\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"18,1,1,0,0\"\u003e\u003cb data-path-to-node=\"18,1,1,0,0\" data-index-in-node=\"0\"\u003eIV Injection:\u003c\/b\u003e Administer reconstituted solution slowly over a period of at least 3 minutes.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"18,1,1,1,0\"\u003e\u003cb data-path-to-node=\"18,1,1,1,0\" data-index-in-node=\"0\"\u003eIV Infusion:\u003c\/b\u003e Administer over a period of 10 to 30 minutes.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"18,1,1,2,0\"\u003e\u003cb data-path-to-node=\"18,1,1,2,0\" data-index-in-node=\"0\"\u003ePeptic Ulcer Bleeding Protocol:\u003c\/b\u003e Typically administered as an 80mg bolus infusion over 30 minutes, followed by a continuous intravenous infusion of 8mg\/hour for 72 hours, or as directed by the attending gastroenterologist\/intensivist.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n\u003c\/ul\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"18,2,0\"\u003e\u003cb data-path-to-node=\"18,2,0\" data-index-in-node=\"0\"\u003eProfessional Healthcare Use:\u003c\/b\u003e Must be administered exclusively by a qualified healthcare professional in a clinic, hospital, or critical care environment.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n\u003c\/ol\u003e\r\\n\u003ch3 data-path-to-node=\"19\"\u003ePrecautions\u003c\/h3\u003e\r\\n\u003cul data-path-to-node=\"20\"\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003ePrescription-Only Parenteral:\u003c\/b\u003e Strictly for professional medical administration; do not self-administer.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"20,1,0\"\u003eRapid IV bolus administration should be avoided; ensure the injection\/infusion rate follows clinical guidelines to prevent vascular irritation.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"20,2,0\"\u003eDiagnostic evaluation is recommended prior to treatment to rule out gastric malignancy, as PPI therapy can mask warning symptoms (e.g., unintended weight loss, dysphagia, hematemesis).\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"20,3,0\"\u003eExercise caution and adjust maximum dosage in patients with severe hepatic impairment (Child-Pugh Class C).\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"20,4,0\"\u003eConsult an attending physician before use during pregnancy or lactation.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n \t\u003cli\u003e\r\\n\u003cp data-path-to-node=\"20,5,0\"\u003eKeep out of reach of children.\u003c\/p\u003e\r\\n\u003c\/li\u003e\r\\n\u003c\/ul\u003e\r\\n\u003ch3 data-path-to-node=\"21\"\u003eStorage Instructions\u003c\/h3\u003e\r\\n\u003cp data-path-to-node=\"22\"\u003eStore the un-reconstituted vial in a cool, dry place below 30°C, protected from direct light and heat. Once reconstituted, the solution should be used immediately or within 12 hours if kept below 30°C. Do not freeze.\u003c\/p\u003e\r\\n\r\\n\u003ch3 data-path-to-node=\"23\"\u003eManufacturer Information\u003c\/h3\u003e\r\\n\u003cp data-path-to-node=\"24\"\u003eFormulated and manufactured in strict compliance with international pharmaceutical quality standards, dedicated to developing targeted gastroenterology and critical care parenteral therapies that promote tissue healing, safeguard gastrointestinal integrity, and ensure patient recovery.\u003c\/p\u003e\r\\n\r\\n\u003c\/div\u003e\r\\n\u003c\/div\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":44164487839803,"sku":null,"price":359.48,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0695\/4899\/8715\/files\/Esover-Injection-40mg-1-750x750-1.webp?v=1789027859","url":"https:\/\/pharmaservicesgroup.com\/products\/esover-injection-40mg-intravenous-proton-pump-inhibitor-therapy","provider":"Pharma Services Distribution","version":"1.0","type":"link"}